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Title: Part I: The Complex Spikes as One of the Cerebellar Secrets
Authors: Manto, Mario
Triarhou, Lazaros C
Type: Article
Subjects: FRASCATI::Medical and Health sciences::Basic medicine
FRASCATI::Natural sciences::Biological sciences
Keywords: Cerebellum
Complex spikes
Inferior olivary complex
Simple spikes
Subjects MESH: Animals
Cerebellar Cortex
History, 20th Century
Models, Neurological
Nerve Fibers
Olivary Nucleus
Purkinje Cells
Issue Date: Jun-2021
Source: Cerebellum (London, England)
Volume: 20
Issue: 3
First Page: 327
Last Page: 329
Abstract: The olivocerebellar tract has unique morphological, physiological, and developmental properties. Olivocerebellar axons are the source of multiple climbing fibers (CFs). The synapse between CFs and the Purkinje neuron is one of the most powerful excitatory in the central nervous system. Complex spikes are composed of an initial large amplitude spike followed by spikelets. The spatiotemporal patterns of complex/simple spikes complement the rate coding to enhance the accuracy of motor and cognitive processing, and to improve predictions related to internal models. Understanding the role of complex spikes is essential in clarifying how the cerebellar cortex contributes to learning, motor control, cognitive tasks, and the processing of emotions. This Cerebellar Classic is devoted to the pioneering work of Eccles, Llinás, and Sasaki on complex spikes using intracellular recordings from Purkinje neurons.
ISSN: 1473-4222
Electronic ISSN: 1473-4230
Other Identifiers: 10.1007/s12311-021-01243-w
Appears in Collections:Department of Educational & Social Policy

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