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https://ruomo.lib.uom.gr/handle/7000/1343
Τίτλος: | Cytoarchitectonic similarity is a wiring principle of the human connectome |
Συγγραφείς: | Goulas, Alexandros Werner, René Beul, Sarah F Säring, Dennis Heuvel, Martijn van den Triarhou, Lazaros C Hilgetag, Claus C |
Τύπος: | Working Paper |
Θέματα: | FRASCATI::Medical and Health sciences::Basic medicine::Neurosciences (including: Psychophysiology) FRASCATI::Natural sciences::Biological sciences |
Ημερομηνία Έκδοσης: | 2016 |
Τίτλος Τόμου: | Cytoarchitectonic similarity is a wiring principle of the human connectome |
Επιτομή: | Understanding the wiring diagram of the human cerebral cortex is a fundamental challenge in neuroscience. Elemental aspects of its organization remain elusive. Here we examine which structural traits of cortical regions, particularly their cytoarchitecture and thickness, relate to the existence and strength of inter-regional connections. We use the architecture data from the classic work of von Economo and Koskinas and state-of-the-art diffusion-based connectivity data from the Human Connectome Project. Our results reveal a prominent role of the cytoarchitectonic similarity of supragranular layers for predicting the existence and strength of connections. In contrast, cortical thickness similarity was not related to the existence or strength of connections. These results are in line with findings for non-human mammalian cerebral cortices, suggesting overarching wiring principles of the mammalian cerebral cortex. The results invite hypotheses about evolutionary conserved neurobiological mechanisms that give rise to the relation of cytoarchitecture and connectivity in the human cerebral cortex. |
URI: | https://doi.org/10.1101/068254 https://ruomo.lib.uom.gr/handle/7000/1343 |
Αλλοι Προσδιοριστές: | 10.1101/068254 |
Εμφανίζεται στις Συλλογές: | Τμήμα Εκπαιδευτικής & Κοινωνικής Πολιτικής |
Αρχεία σε αυτό το Τεκμήριο:
Αρχείο | Περιγραφή | Μέγεθος | Μορφότυπος | |
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068254v1.full.pdf | Preprint | 4,66 MB | Adobe PDF | Προβολή/Ανοιγμα |
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