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Title: Cytoarchitectonic similarity is a wiring principle of the human connectome
Authors: Goulas, Alexandros
Werner, René
Beul, Sarah F
Säring, Dennis
Heuvel, Martijn van den
Triarhou, Lazaros C
Hilgetag, Claus C
Type: Working Paper
Subjects: FRASCATI::Medical and Health sciences::Basic medicine::Neurosciences (including: Psychophysiology)
FRASCATI::Natural sciences::Biological sciences
Issue Date: 2016
Volume Title: Cytoarchitectonic similarity is a wiring principle of the human connectome
Abstract: Understanding the wiring diagram of the human cerebral cortex is a fundamental challenge in neuroscience. Elemental aspects of its organization remain elusive. Here we examine which structural traits of cortical regions, particularly their cytoarchitecture and thickness, relate to the existence and strength of inter-regional connections. We use the architecture data from the classic work of von Economo and Koskinas and state-of-the-art diffusion-based connectivity data from the Human Connectome Project. Our results reveal a prominent role of the cytoarchitectonic similarity of supragranular layers for predicting the existence and strength of connections. In contrast, cortical thickness similarity was not related to the existence or strength of connections. These results are in line with findings for non-human mammalian cerebral cortices, suggesting overarching wiring principles of the mammalian cerebral cortex. The results invite hypotheses about evolutionary conserved neurobiological mechanisms that give rise to the relation of cytoarchitecture and connectivity in the human cerebral cortex.
Other Identifiers: 10.1101/068254
Appears in Collections:Department of Educational & Social Policy

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